A certain item is no longer available. Or this idiom can also mean, to throw away.
Elvis has left the building:
The show has come to an end. It’s all over.
Killing of a certain ethnic or religious group on a massive scale.
Every Cloud Has A Silver Lining:
Be optimistic, even difficult times will lead to better days.
Everything But The Kitchen Sink:
Almost everything and anything has been included.
Excuse my French:
Please forgive me for cussing.